Protective efficacy of a 62-kilodalton antigen, HIS-62, from the cell wall and cell membrane of Histoplasma capsulatum yeast cells
نویسندگان
چکیده
منابع مشابه
Recognition of Histoplasma capsulatum yeast-cell antigens by human lymphocytes and human T-cell clones.
We have prepared a detergent extract from the cell wall and cell membrane of Histoplasma capsulatum yeast cells that is recognized by T cells from mice immunized with viable organisms or with the extract. A 62-kd antigen from this extract has been isolated and has been shown to be antigenic and to confer protective immunity in mice. In this study, we examined the in vitro proliferative response...
متن کاملAntigenic properties of the cell wall and other fractions of the yeast form of Histoplasma capsulatum.
Pine, Leo (Communicable Disease Center, Atlanta, Ga.), Clarence J. Boone, and Dave McLaughlin. Antigenic properties of the cell wall and other fractions of the yeast form of Histoplasma capsulatum. J. Bacteriol. 91:2158-2168. 1966.-Yeast-form cells of Histoplasma capsulatum were fractionated in an attempt to obtain complement-fixing antigens with greater specificity than those of the currently ...
متن کاملAlterations to the cell wall of Histoplasma capsulatum yeasts during infection of macrophages or epithelial cells.
Many Histoplasma capsulatum strains have alpha-(1,3)-glucan in their cell walls and spontaneously produce variants that lack this polymer. The variants, in contrast to the parents, exist in aberrant shapes within macrophages. Here, the ultrastructure of the parental and variant cell walls was examined. All yeasts had identical electron-lucent, thick walls when grown in broth culture. However, i...
متن کاملIsolation of a new soluble antigen from the yeast phase of Histoplasma capsulatum.
A method is described by which a soluble antigen was prepared from the yeast phase of Histoplasma capsulatum. This soluble preparation had a specificity greater than that of whole-cell yeast-phase antigens. In complement fixation tests with sera from human cases of histoplasmosis, blastomycosis, and coccidioidomycosis, the soluble antigen reacted in 12.1% of 141 tests with heterologous sera, wh...
متن کاملRespiration in the yeast and mycelial phases of Histoplasma capsulatum.
Respiration in the yeast and mycelial phases of Histoplasma capsulatum proceeds via a cytochrome system and an alternate oxidase, both present constitutively. The mycelial cytochrome system is distinguished by an additional partial shunt around the antimycin-sensitive site.
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1991
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.59.12.4459-4464.1991